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N Engl J Med. 2014 Dec 4;371(23):2155-66. doi: 10.1056/NEJMoa1409312. Epub 2014 Nov 16.

Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents.

Collaborators (679)

Mauri L, Kereiakes DJ, Cutlip D, Normand SL, Steg P, Cohen T, Driscoll-Shempp P, Braunwald E, Brindis R, Cohen D, Gershlick A, Gurbel P, Holmes DR Jr, Jacobs A, Lincoff M, Simon DI, Tanguay JF, Weaver D, Windecker S, Wiviott S, Steg P, Meredith I, Ormiston J, Darius H, Gershlick A, Wrobel W, Mauri L, Kereiakes DJ, Bonow R, Davidson C, Neaton J, Wijns W, Bates E, Yancy C, Berger C, Litvak D, AlMahameed A, Kimmelstiel C, Epstein L, Hauser T, McClennen S, Gelfand E, Markis J, Gossman D, Oettgen P, Kannam J, Kociol R, Leary M, Thaler D, Dashe J, Hsieh WH, Lei L, Gao Q, Liu Y, Apruzzese P, Zhao X, Ling S, Yen CH, Song Y, Xiao J, Hermiller J, Krucoff M, Kaplan A, Grantham AJ, Albirini A, Abdel A, Jacobs A, Kabour A, Shakir A, Agarwal A, Jain A, Tang A, Hackshaw B, McLaurin B, Muhlestein BJ, Dearing B, Negus B, Jefferson B, Cassavar D, Fisher D, Lee D, Donovan D, Brill D, Lorenz D, Eich D, Mego D, Rizik D, Kereiakes D, Nukta DE, Westerhausen D, Rivera E, Swank G, Renaldo G, Chang G, Stouffer G, Chrysant G, Tadros G, Elsner G, Mishkel G, Boxberger G, Giugliano G, Yamasaki H, Tamboli H, Jones J, Leggett J, Choi J, Mills J, Bengtson J, Lins J, Chambers J, Marshall J, Williams J Jr, Greenberg J, McPherson J, Wang J, Rashid J, McClure JM, Saucedo J, Aragon J, Baran K, Skelding K, Patel K, Cannon L, Satler L, Gruberg L, Bikkina M, Angirekula M, Studeny M, Goodwin M, Ragosta M, Martinelli M, Chang M, Rinaldi M, Tamberella M, Wyman MR, Kellett M, Shoukfeh M, Farhat N, Shah N, Gigliotti O, Cambier P, Hall P, Zetterlund P, Gordon P, Tolerico P, Kerwin P, Ver Lee P, Chandwaney R, Dave R, Sharma R, Smith R, Matthews R, Yaryura R, Goldweit R, Padgett R, Applegate R, Watson R, Merritt R, Caputo R, Dumasia R, Shaikh S, Sharma S, Dabbous S, Janzer S, Waxman S, Dixon S, King S, Guidera S, Hearne S, Helmy T, Lau T, Martyak T, Pow T, Stuver T, Stys T, Srinivas V, Bachinsky W, Newman W, Crowder W, Chepuri W, Hawa Z, Masud Z, Lee D, Garratt K, Rabinowitz A, Shroff A, Moak A, Kabour A, Rosenthal A, Taussig A, Chhabra A, Pucillo A, White A, Barker B, Bertolet B, Price B, Bhambi B, Watt B, Hassel C, Croft C, Lambert C, Caputo C, McKenzie C, Dobies D, Lewis D, Paniagua D, Lee D, Shaw D, Korban E, Aycock G, Kunz G, Tadros G, Eaton G, Simonian G, Phillips J, Hopkins J, Carr J, Cohn J, Kozina J, Stella J, Tuma J, Kieval J, Giri K, Baran K, Garratt K, Cannon L, Zughaib M, Fisch M, Stewart M, Purvis M, Buchbinder M, Weiss M, Abu-Fadel M, Kelberman M, Tamberella M, Quintana O, Hall P, Ho P, Mullen P, Ver Lee P, Wyman R, Sharma R, Goodroe R, Magorien R, Ganim R, Frankel R, Jobe R, Jumper R, Stoler R, Hill R, Jenkins R, Dube S, Davis S, Martin S, McIntyre S, Lin S, Rowe S, McGarry T, Pow T, Lee T, Felten W, Nicholas W, Phillips W, Khatib Y, Simon D, Kandzari D, Kaplan A, Ahmed AH, Albirini A, Gupta A, Rosenthal A, Ferraro A, Spaedy A, Pratsos A, Jain A, Tang A, O'Shaughnessy C, Kim C, Scott C, Brachfeld C, Fisher D, Churchill D, Griffin D, Roberts D, Henderson D, Kereiakes D, Temizer D, Letts D, Rivera E, Shawl F, Shamoon F, Kiernan F, Pilcher G, Mishkel G, Eaton G, Piegari G, Chen H, Aronow H, Leggett J, Wilson J, Aji J, Strain J, Moses J, Williams J, Greenberg J, Griffin J, Hawkins J, Katopodis J, Marshall J, Wang J, Waltman J, Galichia J, Khaw K, Khaw K, Croce K, Lin L, MacDonald L, Satler L, Tami L, Bikkina M, Unterman M, Lechin M, Rothenberg M, Grabarczyk M, Greenberg M, Leesar M, Hook M, Buchbinder M, Guerrero M, Ball M, Cunningham M, Savage M, Chang M, Jones M, Rinaldi M, Amjadi N, Schechtmann N, Hall P, Flaherty P, Gordon P, Mahoney P, Ramanathan P, Bashir R, Hibbard R, Maholic R, Siegel R, Sundrani R, Germanwala S, Hadeed S, Cook S, Yakubov S, Guidera S, Papadakos S, Bajwa T, Mathew T, Mansouri V, Srinivas V, Gupta V, Colyer W, Kuehl W, Nicholson W, Dillon W, Al-Saghir Y, Masud Z, Cutlip D, Dauerman H, Quraishi A, Marino L, Albirini A, Aslam A, Zankar A, Shah A, Spaedy A, Loussararian A, Jain A, Tang A, Sharaf B, Stein B, McLaurin B, Croft C, Kim C, Malone C, Barker C, Fisher D, Steinberg D, Gumm D, Canaday D, Cutlip D, Deutsch E, Matar F, St Goar F, Baweja G, Myers G, Vetrovec G, Dauerman H, Khatri J, Bengtson J, Fix J, Strain J, Patel JK, Chambers J, Altman J, Collins J, Manley J, Messenger J, Riddick J, Stella J, Pastor-Cervantes J, Boran K, Skelding K, Sandhu L, Jobe L, Walters LG, Malinski M, Ghali M, Chauhan M, Izzo M, Neustel M, Dorogy M, Fejka M, Ball M, Hagley M, Shah N, Amjadi N, Cambier P, Hall P, Flaherty P, Gordon P, Overlie P, Patel R, Kovach R, Stoler R, Caputo R, Kumar S, Hearne S, Papadakos S, Baki T, Tolleson T, Haldis T, LaLonde T, Trageser T, Gardner T, Shapiro T, Mehta V, Leimbach W, Matthai W, Schmidt WR 2nd, Abbud Z, Mauri L, Kereiakes DJ, Muller D, Meredith I, Rankin J, Worthley M, Jepson N, Thompson P, Thompson P, Hendriks R, Whitbourn R, Duffy S, Coufal Z, Novobilsky K, Naplava R, Stasek J, Bressollette E, Vaquette B, Teiger E, Steg G, Rihani R, Darius H, Bergmann MW, Radke P, Sebastian P, Strasser R, Hoffmann S, Behrens S, Moebius-Winkler S, Forster T, Horvath I, Kancz S, Koszegi Z, Devlin G, Hart H, Elliott J, Ormiston J, Abernathy M, Fisher N, Kay P, Harding S, Jaffe W, Hoffmann A, Buszman P, Sosnowski C, Dobrzycki S, Trebacz J, Kornacewicz-Jach Z, Iancu AC, Adamson D, Clifford P, Felmeden D, Gershlick A, Jain A, Irving J, Edmond J, de Belder M, Cook J, Pitt M, O'Kane P, Kelly P, Purcell I, Suresh V, Ahmed A, Albirini A, Moreyra A, Rabinowitz A, Shroff A, Jacobs A, Irimpen A, Taussig A, White A, Shakir A, Ghitis A, Agarwal A, Jain A, Chawla A, Tang A, Bertolet B, Uretsky B, Erickson B, Rama B, McLaurin B, Dearing B, Negus B, Bowers B, Watt B, Lambert C, Shoultz C, Wolfe C, Thieling C, Fisher D, Lee D, Eich D, Goldberg D, Mego D, Rizik D, Safley D, Abbott D, Kereiakes D, Canaday D, Cutlip D, Myears D, Westerhausen D, Ebersole D, Netz D, Kosinski E, Mahmud E, Hockstad E, Shawl F, Shamoon F, Schaer G, Kichura G, Myers G, Kaddissi GI, Ramadurai G, Elsner G, Piegari G, Liberman H, Tamboli HP, Dotani I, Mann JT, Revenaugh J, Fleischhauer JF, Pattanayak J, Aji J, Patel J, Douglas J, Griffin J, Griffin J, Katopodis J, Lopez J, Wang J, Saucedo J, Kieval J, Ramanathan K, Allen K, Atassi K, Clayton K, Croce K, Skelding K, Patel K, Harjai K, Chandrasekhar K, Kalapatapu K, Dean L, Barr L, Satler L, Gruberg L, Chauhan M, Dorogy M, Lurie M, Buchbinder M, Guerrero M, Del Core M, Kelberman M, Lim M, Ragosta M, Rinaldi M, Tamberella M, McClure M, Kellett M, Vidovich M, Effat M, Mirza MA, Khan M, Dib N, Laufer N, Kleiman N, Farhat N, Gigliotti O, Best P, Gordon P, Gurbel P, Luetmer P, Tolerico P, Kerwin P, Ver Lee P, Kraft P, Gonzalez R, Dave R, Prashad R, Quesada R, Aycock R, Randolph R, Bach R, Kettelkamp R, Paulus R, Waters R, Zelman R, Applegate R, Feldman R, Smith R, Watson R, Gammon R, Caputo R, Stella R, Hadeed S, Gupta S, Waxman S, Dixon S, Naidu S, Potluri S, Cook S, Crowley S, Thew S, Marshalko S, Guidera S, Hearne S, Karas S, Manoukian S, Yakubov S, Pollock S, Banerjee S, Allaqaband S, Choi S, Mulukutla S, Addo T, Haldis T, McGarry T, Nygaard T, Pow TK, Larkin T, Caulfield T, Stys T, Gupta V, Marquardt W, Ballard W, French W, Hawa Z, Jafar Z.

Abstract

BACKGROUND:

Dual antiplatelet therapy is recommended after coronary stenting to prevent thrombotic complications, yet the benefits and risks of treatment beyond 1 year are uncertain.

METHODS:

Patients were enrolled after they had undergone a coronary stent procedure in which a drug-eluting stent was placed. After 12 months of treatment with a thienopyridine drug (clopidogrel or prasugrel) and aspirin, patients were randomly assigned to continue receiving thienopyridine treatment or to receive placebo for another 18 months; all patients continued receiving aspirin. The coprimary efficacy end points were stent thrombosis and major adverse cardiovascular and cerebrovascular events (a composite of death, myocardial infarction, or stroke) during the period from 12 to 30 months. The primary safety end point was moderate or severe bleeding.

RESULTS:

A total of 9961 patients were randomly assigned to continue thienopyridine treatment or to receive placebo. Continued treatment with thienopyridine, as compared with placebo, reduced the rates of stent thrombosis (0.4% vs. 1.4%; hazard ratio, 0.29 [95% confidence interval {CI}, 0.17 to 0.48]; P<0.001) and major adverse cardiovascular and cerebrovascular events (4.3% vs. 5.9%; hazard ratio, 0.71 [95% CI, 0.59 to 0.85]; P<0.001). The rate of myocardial infarction was lower with thienopyridine treatment than with placebo (2.1% vs. 4.1%; hazard ratio, 0.47; P<0.001). The rate of death from any cause was 2.0% in the group that continued thienopyridine therapy and 1.5% in the placebo group (hazard ratio, 1.36 [95% CI, 1.00 to 1.85]; P=0.05). The rate of moderate or severe bleeding was increased with continued thienopyridine treatment (2.5% vs. 1.6%, P=0.001). An elevated risk of stent thrombosis and myocardial infarction was observed in both groups during the 3 months after discontinuation of thienopyridine treatment.

CONCLUSIONS:

Dual antiplatelet therapy beyond 1 year after placement of a drug-eluting stent, as compared with aspirin therapy alone, significantly reduced the risks of stent thrombosis and major adverse cardiovascular and cerebrovascular events but was associated with an increased risk of bleeding. (Funded by a consortium of eight device and drug manufacturers and others; DAPT ClinicalTrials.gov number, NCT00977938.).

PMID:
25399658
PMCID:
PMC4481318
DOI:
10.1056/NEJMoa1409312
[Indexed for MEDLINE]
Free PMC Article
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