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Biochem Soc Trans. 2014 Dec;42(6):1512-8. doi: 10.1042/BST20140179.

Protein kinase Cθ: the pleiotropic T-cell signalling intermediate.

Author information

1
*Translational Cell Genetics, Department of Pharmacology and Genetics, Medical University of Innsbruck, Peter Mayr Strasse 1a, A-6020 Innsbruck, Austria.

Abstract

Activating as well as inhibitory circuits tightly regulate T-cell activation thresholds and effector differentiation processes enabling proper immune response outcomes. Recently, an additional molecular link between T-cell receptor signalling and CD4⁺ Th17 cell skewing has been reported, namely that protein kinase C (PKC) θ critically regulates Th17/Th1 phenotypic differentiation and plasticity in CD4⁺ T-cells by selectively acting as a 'reprogramming element' that suppresses Th1-typical genes during Th17-mediated immune activation in order to stabilize a Th17 cell phenotype.

PMID:
25399562
DOI:
10.1042/BST20140179
[Indexed for MEDLINE]

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