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Trends Biochem Sci. 1989 Feb;14(2):62-6.

Multifunctional Ca2+/calmodulin-dependent protein kinase: domain structure and regulation.

Abstract

Cells respond to many hormones, neurotransmitters and growth factors by increasing intracellular Ca2+. This second messenger, in turn, affects cellular function via activation of a novel multifunctional Ca2+/calmodulin-dependent protein kinase. The kinase displays an interesting form of biochemical 'memory'; activation elicits an autophosphorylation which converts it to a Ca2+-independent enzyme that can continue to phosphorylate cellular proteins for some time following termination of the initial Ca2+ stimulus.

PMID:
2539662
DOI:
10.1016/0968-0004(89)90045-5
[Indexed for MEDLINE]

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