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Psychiatry Investig. 2014 Oct;11(4):476-80. doi: 10.4306/pi.2014.11.4.476. Epub 2014 Oct 20.

Association of SNAP-25 Gene Ddel and Mnll Polymorphisms with Adult Attention Deficit Hyperactivity Disorder.

Author information

1
Department of Psychiatry, School of Medicine, Pamukkale University, Denizli, Turkey.
2
Department of Medical Biology and Genetics, School of Medicine, Mersin University, Mersin, Turkey.
3
Department of Childhood and Adolescent Psychiatry, School of Medicine, Pamukkale University, Denizli, Turkey.
4
Department of Psychiatry, Servergazi State Hospital, Denizli, Turkey.
5
School of Health, Muğla University, Muğla, Turkey.

Abstract

OBJECTIVE:

The synaptosomal-associated protein of 25 kDa (SNAP-25) gene is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters. Previously, several studies reported association between SNAP-25 and attention deficit hyperactivity disorder (ADHD). We investigated whether these SNAP-25 polymorphisms (MnlI T/G and DdelI T/C) were also associated with ADHD in the Turkish population.

METHODS:

Our study comprised unrelated 139 subjects who met DSM-IV criteria for ADHD and 73 controls and all were of Turkish origin. Genetic analyses were performed and patients were evaluated with Wender-Utah Rating Scale and Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale.

RESULTS:

SNAP-25 DdelI polymorphism was not associated with ADHD but there was a statistically significant difference between ADHD patients and controls for SNAP-25 MnlI polymorphism. For SNAP-25 MnlI polymorphism patients with G/G genotype of the SNAP-25 gene MnlI polymorphism had higher Wender-Utah scores and higher scores in the 1st and 3rd parts of adult ADD/ADHD Scale.

CONCLUSION:

We detected a significant association of the MnlI polymorphism in our ADHD sample which was similar to previous findings. Our study also revealed that SNAP-25 MnlI polymorphism was also associated with symptom severity of ADHD. This study is also, the first report on the association of SNAP-25 with ADHD in the Turkish population.

KEYWORDS:

ADHD; Genetic; SNAP-25 gene

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