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Angew Chem Int Ed Engl. 2015 Jan 12;54(3):937-40. doi: 10.1002/anie.201408677. Epub 2014 Nov 13.

Construction of Matryoshka-type structures from supercharged protein nanocages.

Author information

1
Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich (Switzerland).

Abstract

Designing nanoscaled hierarchical structures with increasing levels of complexity is challenging. Here we show that electrostatic interactions between two complementarily supercharged protein nanocages can be effectively utilized to create nested Matryoshka-type structures. Cage-within-cage complexes containing spatially ordered iron oxide nanoparticles spontaneously self-assemble upon mixing positively supercharged ferritin compartments with AaLS-13, a larger shell-forming protein with a negatively supercharged lumen. Exploiting engineered Coulombic interactions and protein dynamics in this way opens up new avenues for creating hierarchically organized supramolecular assemblies for application as delivery vehicles, reaction chambers, and artificial organelles.

KEYWORDS:

hierarchical structures; nanoparticles; protein engineering; self-assembly; supramolecular chemistry

PMID:
25392947
DOI:
10.1002/anie.201408677
[Indexed for MEDLINE]

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