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J Neurosci. 2014 Nov 12;34(46):15170-7. doi: 10.1523/JNEUROSCI.3236-14.2014.

Novel RNA modifications in the nervous system: form and function.

Author information

1
National Institute on Drug Abuse, Bethesda, Maryland 20892, satterleej@nida.nih.gov.
2
RNA Institute, State University at Albany, Albany, New York 12222.
3
Wellcome Trust, Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom.
4
Stanford University, Department of Genetics, Stanford, California 94305.
5
Department of Pharmacology, Weill Medical College, Cornell University, New York, New York 10065.
6
National Institute on Drug Abuse, Bethesda, Maryland 20892.
7
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, Massachusetts 02129-4404, and.
8
Max-Delbrück-Centrum für Molekulare Medizin, 13092 Berlin, Germany.

Abstract

Modified RNA molecules have recently been shown to regulate nervous system functions. This mini-review and associated mini-symposium provide an overview of the types and known functions of novel modified RNAs in the nervous system, including covalently modified RNAs, edited RNAs, and circular RNAs. We discuss basic molecular mechanisms involving RNA modifications as well as the impact of modified RNAs and their regulation on neuronal processes and disorders, including neural fate specification, intellectual disability, neurodegeneration, dopamine neuron function, and substance use disorders.

PMID:
25392485
PMCID:
PMC4402329
DOI:
10.1523/JNEUROSCI.3236-14.2014
[Indexed for MEDLINE]
Free PMC Article

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