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Brief Funct Genomics. 2016 Jan;15(1):1-9. doi: 10.1093/bfgp/elu042. Epub 2014 Nov 11.

Do it yourself guide to genome assembly.


Bioinformatics skills required for genome sequencing often represent a significant hurdle for many researchers working in computational biology. This humble effort highlights the significance of genome assembly as a research area, focuses on its need to remain accurate, provides details about the characteristics of the raw data, examines some key metrics, emphasizes some tools and draws attention to a generic tutorial with example data that outlines the whole pipeline for next-generation sequencing. The article concludes by pointing out some major future research problems.


Eulerian path; comparative assembly; de novo assembly; de-Bruijn graphs; genome assembly; next-generation sequencing

[Indexed for MEDLINE]

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