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Biochem Biophys Res Commun. 1989 Mar 31;159(3):1128-34.

A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage.

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Institute of Life Science and National Tsing Hua University, Taiwan, R.O.C.


Withangulatin A, a new compound with a known chemical structure and from the antitumor Chinese herb Physalis angulata L, was found to act on topoisomerase II to induce topoisomerase II-mediated DNA damage in vitro. It has two effective dosage ranges of approximate 0.5 and 20 microM, with about one-third the activity of 20 microM VM-26.

[Indexed for MEDLINE]

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