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Retin Cases Brief Rep. 2011 Fall;5(4):360-2. doi: 10.1097/ICB.0b013e3182160939.

Multifocal choroiditis secondary to the reactivation of epstein-barr virus.

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From the Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky.



To describe a case of multifocal choroiditis associated with Epstein-Barr virus reactivation in a patient who had previously had documented infectious mononucleosis.


Color photos, fluorescein angiography, autofluorescence, indocyanine green angiography, and high-definition optical coherence tomography imaging was performed. A 39-year-old woman presented with a central scotoma in her left eye. At 19 years of age, she developed a peripapillary choroidal neovascular complex in her right eye, which was treated by laser photocoagulation. Two weeks before her visual complaint, she suffered from a frontal headache, occipital lymphadenopathy, and splenomegaly.


Laboratory studies revealed markedly elevated immunoglobulin G titers to Epstein-Barr virus and she recalled a history of infectious mononucleosis at 20 years of age.


While primary infection may manifest as infectious mononucleosis, like other viruses in the herpes virus family, there may be reactivation of the virus later in life.

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