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Retin Cases Brief Rep. 2012 Summer;6(3):326-9. doi: 10.1097/ICB.0b013e3182378dd8.

Rosai-dorfman disease diagnosed because of bilateral choroidal masses.

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Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky.



To describe a case of bilateral choroidal masses leading to the diagnosis of Rosai-Dorfman disease.


Case report. Color photographs, fluorescein angiography, autofluorescence, indocyanine green angiography, and high-definition optical coherence tomography imaging of both eyes and computed tomography and biopsy of pelvis mass were performed. A 47-year-lady presented with unknown choroidal masses in both eyes. She had no visual complaints. Her medical history was noncontributory.


Workup included a computed tomography of the chest and abdomen that demonstrated soft tissue masses in the renal pelvis bilaterally. A core needle biopsy from the renal mass demonstrated numerous histiocytoid that were positive for CD163 and S100 protein.


Based on this spectrum of findings, the diagnosis of Rosai-Dorfman disease was made. To date, the patient has been followed-up for 3 years without medical intervention and without visual deterioration. Careful follow-up is a reasonable management if patients are asymptomatic.

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