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Clin Infect Dis. 2015 Mar 1;60(5):741-9. doi: 10.1093/cid/ciu871. Epub 2014 Nov 10.

Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study.

Collaborators (318)

Clara L, Sanchez M, Nacinovich F, Oses PF, Ronderos R, Sucari A, Thierer J, Casabé J, Cortes C, Altclas J, Kogan S, Spelman D, Athan E, Harris O, Kennedy K, Tan R, Gordon D, Papanicolas L, Eisen D, Grigg L, Street A, Korman T, Kotsanas D, Dever R, Jones P, Konecny P, Lawrence R, Rees D, Ryan S, Feneley MP, Harkness J, Jones P, Ryan S, Jones P, Ryan S, Jones P, Post J, Reinbott P, Ryan S, Gattringer R, Wiesbauer F, Andrade AR, de Brito AC, Guimarães AC, Grinberg M, Mansur AJ, Siciliano RF, Strabelli TM, Vieira ML, de Medeiros Tranchesi RA, Paiva MG, Fortes CQ, de Oliveira Ramos A, Ferraiuoli G, Golebiovski W, Lamas C, Santos M, Weksler C, Karlowsky JA, Keynan Y, Morris AM, Rubinstein E, Jones SB, Garcia P, Cereceda M, Fica A, Mella RM, Barsic B, Bukovski S, Krajinovic V, Pangercic A, Rudez I, Vincelj J, Freiberger T, Pol J, Zaloudikova B, Ashour Z, El Kholy A, Mishaal M, Rizk H, Aissa N, Alauzet C, Alla F, Campagnac C, Doco-Lecompte T, Selton-Suty C, Casalta JP, Fournier PE, Habib G, Raoult D, Thuny F, Delahaye F, Delahaye A, Vandenesch F, Donal E, Donnio PY, Michelet C, Revest M, Tattevin P, Violette J, Chevalier F, Jeu A, Sorel C, Tribouilloy C, Bernard Y, Chirouze C, Hoen B, Leroy J, Plesiat P, Naber C, Neuerburg C, Mazaheri B, Naber C, Neuerburg C, Athanasia S, Giannitsioti E, Mylona E, Paniara O, Papanicolaou K, Pyros J, Skoutelis A, Sharma G, Francis J, Nair L, Thomas V, Venugopal K, Hannan M, Hurley J, Gilon D, Israel S, Korem M, Strahilevitz J, Rubinstein E, Strahilevitz J, Casillo R, Cuccurullo S, Dialetto G, Durante-Mangoni E, Irene M, Ragone E, Tripodi MF, Utili R, Cecchi E, De Rosa F, Forno D, Imazio M, Trinchero R, Tebini A, Grossi P, Lattanzio M, Toniolo A, Goglio A, Raglio A, Ravasio V, Rizzi M, Suter F, Carosi G, Magri S, Signorini L, Baban T, Kanafani Z, Kanj SS, Yasmine M, Abidin I, Tamin SS, Martínez ER, Soto Nieto GI, van der Meer JT, Chambers S, Holland D, Morris A, Raymond N, Read K, Murdoch DR, Dragulescu S, Ionac A, Mornos C, Butkevich OM, Chipigina N, Kirill O, Vadim K, Vinogradova T, Edathodu J, Halim M, Lum LN, Tan RS, Lejko-Zupanc T, Logar M, Mueller-Premru M, Commerford P, Commerford A, Deetlefs E, Hansa C, Ntsekhe M, Almela M, Armero Y, Azqueta M, Castañeda X, Cervera C, Del Rio A, Falces C, Garcia-de-la-Maria C, Fita G, Gatell JM, Marco F, Mestres CA, Miró JM, Moreno A, Ninot S, Paré C, Pericas J, Ramirez J, Rovira I, Sitges M, Anguera I, Font B, Guma JR, Bermejo J, Bouza E, Fernández MA, Gonzalez-Ramallo V, Marín M, Muñoz P, Pedromingo M, Roda J, Rodríguez-Créixems M, Solis J, Almirante B, Fernandez-Hidalgo N, Tornos P, de Alarcón A, Parra R, Alestig E, Johansson M, Olaison L, Snygg-Martin U, Pachirat O, Pachirat P, Pussadhamma B, Senthong V, Casey A, Elliott T, Lambert P, Watkin R, Eyton C, Klein JL, Bradley S, Kauffman C, Bedimo R, Chu VH, Corey GR, Crowley AL, Douglas P, Drew L, Fowler VG, Holland T, Lalani T, Mudrick D, Samad Z, Sexton D, Stryjewski M, Wang A, Woods CW, Lerakis S, Cantey R, Steed L, Wray D, Dickerman SA, Bonilla H, DiPersio J, Salstrom SJ, Baddley J, Patel M, Peterson G, Stancoven A, Afonso L, Kulman T, Levine D, Rybak M, Cabell CH, Baloch K, Chu VH, Corey GR, Dixon CC, Fowler VG, Harding T, Jones-Richmond M, Pappas P, Park LP, Redick T, Stafford J, Anstrom K, Athan E, Bayer AS, Cabell CH, Chu VH, Corey GR, Fowler VG, Hoen B, Karchmer AW, Miró JM, Murdoch DR, Sexton DJ, Wang A, Bayer AS, Cabell CH, Chu V, Corey GR, Durack DT, Eykyn S, Fowler VG, Hoen B, Miró JM, Moreillon P, Olaison L, Raoult D, Rubinstein E, Sexton DJ.

Author information

1
UMR CNRS 6249 Chrono-Environnement, Université de Franche-Comté Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Régional Universitaire, Besançon.
2
Université de Lorraine, Université Paris Descartes, Apemac, EA4360 INSERM, CIC-EC, CIE6 CHU Nancy, Pôle S2R, Epidémiologie et Evaluation Cliniques, Nancy, France.
3
Department of Medicine, Duke University Medical Center, Durham, North Carolina.
4
INSERM, CIC-EC, CIE6 CHU Nancy, Pôle S2R, Epidémiologie et Evaluation Cliniques, Nancy, France.
5
Department of Cardiothoracic Sciences, University of Naples S.U.N., Monaldi Hospital, Italy.
6
Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
7
Fourth Department of Internal Medicine, Attikon University General Hospital, Athens, Greece.
8
Department of Microbiology, Mater Misericordiae University Hospital, Dublin, Ireland.
9
Department of Infectious Diseases, Medical Centre Ljubljana, Slovenia.
10
Hospital Clinic-IDIBAPS, University of Barcelona.
11
Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
12
Microbiology Unit, Canterbury Health Laboratories, Christchurch, New Zealand.
13
Maladies Infectieuses et Réanimation Médicale, Pontchaillou University Hospital, Rennes.
14
Départment de Cardiologie, Hôpital Universitaire Sud, Amiens.
15
UMR CNRS 6249 Chrono-Environnement, Université de Franche-Comté Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Régional Universitaire, Besançon Université des Antilles et de la Guyane, Faculté de Médecine Hyacinthe Bastaraud, EA 4537, Pointe-à-Pitre, Guadeloupe Service de Maladies Infectieuses et Tropicales, CIC 1424, Centre Hospitalier Universitaire, Pointe-à-Pitre, France.

Abstract

BACKGROUND:

The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study.

METHODS:

Participants were enrolled between June 2000 and December 2006. Cox proportional hazards modeling that included surgery as a time-dependent covariate and propensity adjustment for likelihood to receive cardiac surgery was used to evaluate the impact of EVS and 1-year all-cause mortality on patients with definite left-sided S. aureus PVIE and no history of injection drug use.

RESULTS:

EVS was performed in 74 of the 168 (44.3%) patients. One-year mortality was significantly higher among patients with S. aureus PVIE than in patients with non-S. aureus PVIE (48.2% vs 32.9%; P = .003). Staphylococcus aureus PVIE patients who underwent EVS had a significantly lower 1-year mortality rate (33.8% vs 59.1%; P = .001). In multivariate, propensity-adjusted models, EVS was not associated with 1-year mortality (risk ratio, 0.67 [95% confidence interval, .39-1.15]; P = .15).

CONCLUSIONS:

In this prospective, multinational cohort of patients with S. aureus PVIE, EVS was not associated with reduced 1-year mortality. The decision to pursue EVS should be individualized for each patient, based upon infection-specific characteristics rather than solely upon the microbiology of the infection causing PVIE.

KEYWORDS:

1-year mortality; endocarditis; prosthetic valve; surgery

PMID:
25389255
PMCID:
PMC4366581
DOI:
10.1093/cid/ciu871
[Indexed for MEDLINE]
Free PMC Article

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