Format

Send to

Choose Destination
Cephalalgia. 2015 Aug;35(9):776-82. doi: 10.1177/0333102414557841. Epub 2014 Nov 11.

Replication study of previous migraine genome-wide association study findings in a Spanish sample of migraine with aura.

Author information

1
Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain Center for Biomedical Network Research on Rare Diseases (CIBERER)-Institute of Health Carlos III, Spain.
2
Headache and Neurological Pain Laboratory, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Spain Headache Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Spain.
3
Pediatric Neurology Research Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Spain.
4
Neurology Service, Hospital Sant Joan de Déu (Fundació Althaia), Spain.
5
Department of Statistics, University of Barcelona, Spain.
6
Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain Center for Biomedical Network Research on Rare Diseases (CIBERER)-Institute of Health Carlos III, Spain bcormand@ub.edu.

Abstract

BACKGROUND:

Migraine is a common disabling condition that affects approximately 15% of the population. Several genome-wide association studies have attempted to identify susceptibility variants involved in migraine, reporting several candidate loci for the disorder.

METHODS:

In order to replicate findings from previous genome-wide association studies, a case-control association study was performed. Twelve single nucleotide polymorphisms were genotyped in a Spanish sample of 512 migraine with aura patients and 535 migraine-free controls.

RESULTS:

Nominal associations were found for single nucleotide polymorphisms rs2651899 (within the PRDM16 gene), rs10166942 (near TRPM8), rs12134493 (close to TSPAN2) and rs10504861 (near MMP16) in our migraine with aura sample.

CONCLUSIONS:

Our study provides suggestive replication, in a Spanish migraine with aura sample, of four genome-wide association study findings previously reported in common migraine. However, larger sample sets should be explored to confirm our results.

KEYWORDS:

MMP16; Migraine with aura; PRDM16; TRPM8; TSPAN2; association study

PMID:
25388962
DOI:
10.1177/0333102414557841
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center