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Viruses. 2014 Nov 7;6(11):4258-64. doi: 10.3390/v6114258.

Twenty years of KSHV.

Author information

1
Cancer Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA. yc70@pitt.edu.
2
Cancer Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA. psm9@pitt.edu.

Abstract

Twenty years ago, Kaposi's sarcoma (KS) was the oncologic counterpart to Winston Churchill's Russia: a riddle, wrapped in a mystery, inside an enigma. First described by Moritz Kaposi in 1872, who reported it to be an aggressive skin tumor, KS became known over the next century as a slow-growing tumor of elderly men-in fact, most KS patients were expected to die with the tumor rather than from it. Nevertheless, the course and manifestations of the disease varied widely in different clinical contexts. The puzzle of KS came to the forefront as a harbinger of the AIDS epidemic. The articles in this issue of Viruses recount progress made in understanding Kaposi's sarcoma herpesvirus (KSHV) since its initial description in 1994.

PMID:
25386844
PMCID:
PMC4246220
DOI:
10.3390/v6114258
[Indexed for MEDLINE]
Free PMC Article

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