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Int J Biol Markers. 2014 Dec 9;29(4):e440-4. doi: 10.5301/jbm.5000109.

Case report: postradiation chondrosarcoma with a short latency period of 6 months.

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3 Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu - China.


We describe a case of postradiation chondrosarcoma after basal cell carcinoma treatment. At the time he presented, the patient was a 35-year-old man who had received radiotherapy at a dose of 70 Gy for 8 weeks. Six months after radiation treatment, a rapidly growing mass at the upper right alveolar ridge of the gums, where radiation had been given, was diagnosed as chondrosarcoma. Generally, chondrosarcoma occurs after a latency period of several years following radiation. However, there are a few relevant reports indicating that maxillofacial chondrosarcoma can develop after radiotherapy for basal cell carcinoma, with a short latency of 6 months. We hypothesize that the dosage and treatment time of radiation may have played a role in the opening/closing of the Hh-signaling pathway in the case of this patient.

[Indexed for MEDLINE]

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