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F1000Res. 2014 May 9;3:104. doi: 10.12688/f1000research.3894.1. eCollection 2014.

Simple, biologically-constrained CA1 pyramidal cell models using an intact, whole hippocampus context.

Author information

1
Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada ; Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada.
2
Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, H4G 1X6, Canada.
3
Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada ; Department of Medicine (Neurology), Physiology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada.

Abstract

The hippocampus is a heavily studied brain structure due to its involvement in learning and memory. Detailed models of excitatory, pyramidal cells in hippocampus have been developed using a range of experimental data. These models have been used to help us understand, for example, the effects of synaptic integration and voltage gated channel densities and distributions on cellular responses. However, these cellular outputs need to be considered from the perspective of the networks in which they are embedded. Using modeling approaches, if cellular representations are too detailed, it quickly becomes computationally unwieldy to explore large network simulations. Thus, simple models are preferable, but at the same time they need to have a clear, experimental basis so as to allow physiologically based understandings to emerge. In this article, we describe the development of simple models of CA1 pyramidal cells, as derived in a well-defined experimental context of an intact, whole hippocampus preparation expressing population oscillations. These models are based on the intrinsic properties and frequency-current profiles of CA1 pyramidal cells, and can be used to build, fully examine, and analyze large networks.

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