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Clin J Pain. 2015 Jun;31(6):504-16. doi: 10.1097/AJP.0000000000000176.

Individualized Guided Internet-delivered Cognitive-Behavior Therapy for Chronic Pain Patients With Comorbid Depression and Anxiety: A Randomized Controlled Trial.

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*Department of Psychology †Pain Research, Department of Surgical Sciences, Uppsala University ‡Department of Behavioural Sciences and Learning, Linköping University, Linköping University §Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.



Depression and anxiety are commonly seen in patients with chronic pain which affects the patient's daily life functioning. Although considerable attention has been devoted to explain why depression and anxiety are frequent comorbid with chronic pain, little empirical work has been conducted on interventions that target depression and anxiety and chronic pain. The present study was designed to test an individualized cognitive-behavioral treatment delivered through the internet for persons with chronic pain and emotional distress.


A total of 52 patients with chronic pain and depression were included and randomized to either treatment for 8 weeks or to a control group that participated in a moderated online discussion forum.


Intent-to-treat analyses showed significant decreases regarding depressive symptoms and pain disability in the treatment group. Results on the primary outcomes of depression and anxiety were in favor of the treatment group. Reductions were also found on pain catastrophizing.


One-year follow-up showed maintenance of improvements. We conclude that an individualized guided internet-delivered treatment based on cognitive-behavior therapy can be effective for persons with chronic pain comorbid emotional distress.

[Indexed for MEDLINE]

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