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Nucleic Acids Res. 2015 Jan;43(Database issue):D618-23. doi: 10.1093/nar/gku1105. Epub 2014 Nov 6.

MyMpn: a database for the systems biology model organism Mycoplasma pneumoniae.

Author information

1
EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain Theoretical Biophysics, Humboldt-Universitt zu Berlin, Invalidenstr 42, 10115 Berlin, Germany guglielmo.roma@crg.eu luis.serrano@crg.eu.
2
Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain CRG Bioinformatics Facility, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain.
3
EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain.
4
EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluis Companys 23, 08010 Barcelona, Spain.
5
Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain CRG Bioinformatics Facility, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain guglielmo.roma@crg.eu luis.serrano@crg.eu.

Abstract

MyMpn (http://mympn.crg.eu) is an online resource devoted to studying the human pathogen Mycoplasma pneumoniae, a minimal bacterium causing lower respiratory tract infections. Due to its small size, its ability to grow in vitro, and the amount of data produced over the past decades, M. pneumoniae is an interesting model organisms for the development of systems biology approaches for unicellular organisms. Our database hosts a wealth of omics-scale datasets generated by hundreds of experimental and computational analyses. These include data obtained from gene expression profiling experiments, gene essentiality studies, protein abundance profiling, protein complex analysis, metabolic reactions and network modeling, cell growth experiments, comparative genomics and 3D tomography. In addition, the intuitive web interface provides access to several visualization and analysis tools as well as to different data search options. The availability and--even more relevant--the accessibility of properly structured and organized data are of up-most importance when aiming to understand the biology of an organism on a global scale. Therefore, MyMpn constitutes a unique and valuable new resource for the large systems biology and microbiology community.

PMID:
25378328
PMCID:
PMC4383923
DOI:
10.1093/nar/gku1105
[Indexed for MEDLINE]
Free PMC Article

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