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Adv Healthc Mater. 2015 Mar 11;4(4):534-9. doi: 10.1002/adhm.201400410. Epub 2014 Nov 5.

Hydrogel design of experiments methodology to optimize hydrogel for iPSC-NPC culture.

Author information

1
Biomedical Engineering Department, University of California, Los Angeles, CA, USA.

Abstract

Bioactive signals can be incorporated in hydrogels to direct encapsulated cell behavior. Design of experiments methodology methodically varies the signals systematically to determine the individual and combinatorial effects of each factor on cell activity. Using this approach enables the optimization of three ligands concentrations (RGD, YIGSR, IKVAV) for the survival and differentiation of neural progenitor cells.

KEYWORDS:

design of experiments; hyaluronic acid; hydrogel; induced pluripotent stem cells; neurons

PMID:
25378176
PMCID:
PMC4384641
DOI:
10.1002/adhm.201400410
[Indexed for MEDLINE]
Free PMC Article

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