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Adv Mater. 2015 Jan 7;27(1):73-8. doi: 10.1002/adma.201403702. Epub 2014 Nov 6.

pH-stimulated DNA hydrogels exhibiting shape-memory properties.

Author information

1
The Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.

Abstract

Nucleic acid-functionalized polyacrylamide chains that are cooperatively cross-linked by i-motif and nucleic acid duplex units yield, at pH 5.0, DNA hydrogels exhibiting shape-memory properties. Separation of the i-motif units at pH 8.0 dissolves the hydrogel into a quasi-liquid phase. The residual duplex units provide, however, a memory code in the quasi-liquid allowing the regeneration of the hydrogel shape at pH 5.0.

KEYWORDS:

acrylamide; gel; i-motif; nucleic acid; switch

PMID:
25377247
DOI:
10.1002/adma.201403702
[Indexed for MEDLINE]

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