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Biomed Environ Sci. 2014 Nov;27(11):907-11. doi: 10.3967/bes2014.128.

90d Exposure to Nonylphenol has Adverse Effects on the Spermatogenesis and Sperm Maturation of Adult Male Rats.

Author information

1
Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China; KunShan Health Inspection Station, 458 Tongfeng Road, Kunshan 215301, Jiangsu, China.
2
Experimental Center of Medical College, Soochow University, Suzhou 215123, Jiangsu, China.
3
Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China; The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang, China.
4
Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China.

Abstract

This study was conducted to elucidate the reproductive effect of NP on testis, epididymis and epididymal sperm in vivo. Adult male Sprague-Dawley rats were gavaged with NP at 0, 40, 100, or 250 mg/kg body weight (bw) on alternate days for 90 d. The results showed that oral administration of NP may damage the structure and function of testis, induce apoptosis and oxidative stress in epididymis or even have cytotoxic effects on epididymal sperm.

PMID:
25374025
DOI:
10.3967/bes2014.128
[Indexed for MEDLINE]
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