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Cell Rep. 2014 Oct 23;9(2):514-21. doi: 10.1016/j.celrep.2014.09.022. Epub 2014 Oct 16.

In vivo tissue-wide synchronization of mitochondrial metabolic oscillations.

Author information

1
Intracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive 303A, Bethesda, MD 20892-4340, USA.
2
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 10 Center Drive 6B17, Bethesda, MD 20892, USA.
3
Intracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive 303A, Bethesda, MD 20892-4340, USA. Electronic address: weigertr@mail.nih.gov.

Abstract

Little is known about the spatiotemporal coordination of mitochondrial metabolism in multicellular organisms in situ. Using intravital microscopy in live animals, we report that mitochondrial metabolism undergoes rapid and periodic oscillations under basal conditions. Notably, mitochondria in vivo behave as a network of functionally coupled oscillators, which maintain a high level of coordination throughout the tissue via the activity of gap junctions. These findings reveal a unique aspect of the relationship between tissue architecture and self-organization of mitochondrial metabolism in vivo.

PMID:
25373899
PMCID:
PMC4223640
DOI:
10.1016/j.celrep.2014.09.022
[Indexed for MEDLINE]
Free PMC Article

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