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Mol Cell Endocrinol. 1989 Feb;61(2):239-46.

Opposite effects of estrogen and catecholestrogen on hormone-sensitive breast cancer cell growth and differentiation.

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1
Laboratoire d'Endocrinologie Expérimentale, Centre Oscar Lambret, Lille, France.

Abstract

Catecholestrogens and especially 2-hydroxyestrone (2OH-E1) are estradiol metabolites locally formed in breast cancer cells. The present study demonstrates that the two parent compounds, estradiol (E2) and its metabolite 2OH-E1, exert opposite effects on hormone-sensitive breast cancer cell growth assessed by cell counts and transferrin receptor levels, and also on cell differentiation assessed by secreted proteins such as alpha-lactalbumin and gross cystic disease fluid protein (GCDFP-15). The present findings may highlight estradiol regulation in hormone-sensitive breast cancer cells.

PMID:
2537243
DOI:
10.1016/0303-7207(89)90135-4
[Indexed for MEDLINE]

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