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J Signal Transduct. 2014;2014:173026. doi: 10.1155/2014/173026. Epub 2014 Oct 13.

Signaling Network Map of Endothelial TEK Tyrosine Kinase.

Author information

1
Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore 560066, India ; School of Biotechnology, KIIT University, Bhubaneswar 751024, India.
2
Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore 560066, India.
3
Dr. M.G.R. Educational and Research Institute, Maduravoyal, Chennai 600095, India.
4
Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore 560066, India ; Manipal University, Madhav Nagar, Manipal 576104, India.
5
School of Biotechnology, KIIT University, Bhubaneswar 751024, India.
6
Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
7
Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore 560066, India ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

TEK tyrosine kinase is primarily expressed on endothelial cells and is most commonly referred to as TIE2. TIE2 is a receptor tyrosine kinase modulated by its ligands, angiopoietins, to regulate the development and remodeling of vascular system. It is also one of the critical pathways associated with tumor angiogenesis and familial venous malformations. Apart from the vascular system, TIE2 signaling is also associated with postnatal hematopoiesis. Despite the involvement of TIE2-angiopoietin system in several diseases, the downstream molecular events of TIE2-angiopoietin signaling are not reported in any pathway repository. Therefore, carrying out a detailed review of published literature, we have documented molecular signaling events mediated by TIE2 in response to angiopoietins and developed a network map of TIE2 signaling. The pathway information is freely available to the scientific community through NetPath, a manually curated resource of signaling pathways. We hope that this pathway resource will provide an in-depth view of TIE2-angiopoietin signaling and will lead to identification of potential therapeutic targets for TIE2-angiopoietin associated disorders.

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