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Nat Rev Mol Cell Biol. 2014 Dec;15(12):771-85. doi: 10.1038/nrm3902. Epub 2014 Nov 5.

Extracellular matrix assembly: a multiscale deconstruction.

Author information

1
Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco.
2
1] Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco. [2] University of California San Francisco and University of California Berkeley Joint Graduate Group in Bioengineering, San Francisco, California 94143, USA.
3
1] Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco. [2] Department of Anatomy, University of California, San Francisco. [3] Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco. [4] Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco. [5] UCSF Helen Diller Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA.

Abstract

The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.

PMID:
25370693
PMCID:
PMC4682873
DOI:
10.1038/nrm3902
[Indexed for MEDLINE]
Free PMC Article
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