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Nature. 1989 Feb 9;337(6207):525-31.

Designing CD4 immunoadhesins for AIDS therapy.

Author information

1
Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080.

Abstract

A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use.

PMID:
2536900
DOI:
10.1038/337525a0
[Indexed for MEDLINE]

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