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Gut Liver. 2014 Nov;8(6):590-7. doi: 10.5009/gnl14081. Epub 2014 Nov 15.

An overview of eosinophilic esophagitis.

Author information

1
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease affecting both children and adults. The condition is characterized by an eosinophilic infiltration of the esophageal epithelium. Symptoms of esophageal dysfunction include dysphagia, food impaction and symptoms mimicking gastroesophageal reflux disease. Endoscopic examination typically reveals mucosal fragility, ring or corrugated mucosa, longitudinal furrows, whitish plaques or a small caliber esophagus. Histologic findings of >15 eosinophils per high-power field is the diagnostic hallmark of EoE. An elimination diet, topical corticosteroids or endoscopic dilation for fibrostenotic disease serve as effective therapeutic option.

KEYWORDS:

Eosinophilic esophagitis; Gastroesophageal reflux; High-power field

PMID:
25368745
PMCID:
PMC4215443
DOI:
10.5009/gnl14081
[Indexed for MEDLINE]
Free PMC Article

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