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Anticancer Res. 2014 Nov;34(11):6601-7.

Role of interferon-alpha in patients with neuroendocrine tumors: a retrospective study.

Author information

1
Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, London, U.K.
2
Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, London, U.K. m.caplin@ucl.ac.uk.

Abstract

BACKGROUND/AIM:

Interferon alpha (IFNα) is used sparingly in the management of neuroendocrine tumors (NETs) due to toxicity and perceived limited efficacy. Other medical therapeutic options include somatostatin analogues and molecular-targeted agents, as well as chemotherapy and radionuclide targeted-therapy. The aim of the present study was to perform a retrospective analysis of patients treated with IFNα.

PATIENTS AND METHODS:

Patients were identified from the NET database. Radiological, biochemical and symptomatic response were assessed. Progression-free survival (PFS), adverse events and toxicities were recorded.

RESULTS:

Thirty-five patients were treated with IFNα, with a mean age of 60.1 (range=38-85) years; eight patients (23%) withdrew before 3 months, one (3%) had complete response; there was one partial response; 25 patients (71%) had at least three months of stable disease. The median PFS was 25 months.

CONCLUSION:

IFNα demonstrated efficacy and was reasonably tolerated. IFNα may still have a role in small-volume diffuse disease, in syndromic patients where there is resistance to somatostatin analogue, or as a bridge to other therapies.

KEYWORDS:

Interferon-alpha; neuroendocrine tumours

PMID:
25368264
[Indexed for MEDLINE]

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