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Anticancer Res. 2014 Nov;34(11):6327-32.

Effect of Withania somnifera root extract on spontaneous estrogen receptor-negative mammary cancer in MMTV/Neu mice.

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Department of Biomedical Sciences School of Veterinary Medicine, Tuskegee University, Tuskegee, AL, U.S.A.
Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, U.S.A.
Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, U.S.A.


The cancer-preventive activity of an extract of Withania somnifera (WS) roots was examined in female transgenic (MMTV/Neu) mice that received a diet containing the extract (750 mg/kg of diet) for 10 months. Mice in the treated group (n=35) had an average of 1.66 mammary carcinomas, and mice in the control group (n=33) had 2.48, showing a reduction of 33%. The average weights of the carcinomas were 2.36 g for mice in the treated group and 2.63 g for the controls, a difference of 10%. Labeling indices for Ki67 and proliferating cell nuclear antigen marker in mammary carcinomas of the treated group were 35% and 30% lower, respectively, than those of the corresponding control group. Expression of the chemokine was reduced by 50%. These results indicate that the root extract reduced the number of mammary carcinomas that developed and reduced the rate of cell division in the carcinomas.


Withania; chemoprevention; mammary cancer; mice

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