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Anticancer Res. 2014 Nov;34(11):6327-32.

Effect of Withania somnifera root extract on spontaneous estrogen receptor-negative mammary cancer in MMTV/Neu mice.

Author information

1
Department of Biomedical Sciences School of Veterinary Medicine, Tuskegee University, Tuskegee, AL, U.S.A.
2
Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, U.S.A.
3
Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, U.S.A. clintongrubbs@uabmc.edu.

Abstract

The cancer-preventive activity of an extract of Withania somnifera (WS) roots was examined in female transgenic (MMTV/Neu) mice that received a diet containing the extract (750 mg/kg of diet) for 10 months. Mice in the treated group (n=35) had an average of 1.66 mammary carcinomas, and mice in the control group (n=33) had 2.48, showing a reduction of 33%. The average weights of the carcinomas were 2.36 g for mice in the treated group and 2.63 g for the controls, a difference of 10%. Labeling indices for Ki67 and proliferating cell nuclear antigen marker in mammary carcinomas of the treated group were 35% and 30% lower, respectively, than those of the corresponding control group. Expression of the chemokine was reduced by 50%. These results indicate that the root extract reduced the number of mammary carcinomas that developed and reduced the rate of cell division in the carcinomas.

KEYWORDS:

Withania; chemoprevention; mammary cancer; mice

PMID:
25368231
PMCID:
PMC4386658
[Indexed for MEDLINE]
Free PMC Article

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