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J Infect Dis. 2015 Apr 15;211(8):1352-5. doi: 10.1093/infdis/jiu608. Epub 2014 Nov 2.

K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa.

Author information

1
KEMRI/United States Army Medical Research Unit-Kenya, Kisumu.
2
Wellcome Trust Sanger Institute, Hinxton.
3
Navrongo Health Research Centre.
4
National Institute for Medical Research, Tanga, Tanzania.
5
Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
6
Institut National de Recherche Biomédicale, Ecole de Santé Publique/Faculté de Médecine, Université de Kinshasa, Democratic Republic of the Congo.
7
Malaria Research and Control Center, National Institute of Public Health, Abidjan, Côte d'Ivoire.
8
Department of Parasitology and Mycology, Faculty of Medicine, Université des Sciences de la Santé, Libreville, Gabon.
9
University of Buea, Cameroon.
10
Aklilu Lemma Institute of Pathobiology, Addis Ababa University and Armauer Hansen Research Institute, Ethiopia.
11
Institut Pasteur de Madagascar, Antananarivo.
12
Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Mali Benhard-Nocht Institute for Tropical Medicine, Hamburg, Germany.
13
Medical Research Council, Gambia Unit, Serekunda.
14
Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
15
Wellcome Trust Sanger Institute, Hinxton Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
16
Wellcome Trust Sanger Institute, Hinxton Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Mali.

Erratum in

Abstract

Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.

KEYWORDS:

K13-propeller; artemisinin resistance; sub-Saharan Africa

PMID:
25367300
PMCID:
PMC4827505
DOI:
10.1093/infdis/jiu608
[Indexed for MEDLINE]
Free PMC Article

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