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Genes Dev. 2014 Nov 1;28(21):2331-47. doi: 10.1101/gad.250647.114.

Pericellular proteolysis in cancer.

Author information

1
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10065, USA.
2
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10065, USA johanna@joycelab.org.

Abstract

Pericellular proteases have long been associated with cancer invasion and metastasis due to their ability to degrade extracellular matrix components. Recent studies demonstrate that proteases also modulate tumor progression and metastasis through highly regulated and complex processes involving cleavage, processing, or shedding of cell adhesion molecules, growth factors, cytokines, and kinases. In this review, we address how cancer cells, together with their surrounding microenvironment, regulate pericellular proteolysis. We dissect the multitude of mechanisms by which pericellular proteases contribute to cancer progression and discuss how this knowledge can be integrated into therapeutic opportunities.

KEYWORDS:

invasion; macrophages; metastasis; migration; proteases; tumor microenvironment

PMID:
25367033
PMCID:
PMC4215179
DOI:
10.1101/gad.250647.114
[Indexed for MEDLINE]
Free PMC Article

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