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Exp Cell Res. 1989 Feb;180(2):574-9.

DNA synthesis in mouse brown adipose tissue is under beta-adrenergic control.

Author information

1
Wenner-Gren Institute, University of Stockholm, Sweden.

Abstract

The rate of DNA synthesis in mouse brown adipose tissue was followed with injections of [3H]thymidine. Cold exposure led to a large increase in the rate of [3H]thymidine incorporation, reaching a maximum after 8 days, whereafter the activity abruptly ceased. A series of norepinephrine injections was in itself able to increase [3H]thymidine incorporation. When norepinephrine was injected in combination with the alpha-adrenergic antagonist phentolamine or with the beta-adrenergic antagonist propranolol, the stimulation was fully blocked by propranolol. It is suggested that stimulation of DNA synthesis in brown adipose tissue is a beta-adrenergically mediated process and that the tissue is an interesting model for studies of physiological control of DNA synthesis.

PMID:
2536614
DOI:
10.1016/0014-4827(89)90086-4
[Indexed for MEDLINE]

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