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J Asthma. 2015 May;52(4):382-90. doi: 10.3109/02770903.2014.980509. Epub 2014 Nov 21.

Efficacy of high-dose vitamin D in pediatric asthma: a systematic review and meta-analysis.

Author information

1
Division of Critical Care, Department of Pediatrics, Faculty of Medicine, University of Ottawa, Children's Hospital of Eastern Ontario , Ottawa , Canada .

Abstract

CONTEXT:

Observational studies have suggested a relationship between vitamin D status and asthma-related respiratory outcomes. The benefit of vitamin D supplementation for pulmonary function, symptoms and exacerbations is not well established.

OBJECTIVE:

To systematically review paediatric clinical trials investigating the role of vitamin D on asthma-related respiratory outcomes.

DATA SOURCES:

MEDLINE, EMBASE and CENTRAL were searched until January 2014. No date or language restrictions.

STUDY SELECTION:

Clinical trials reporting asthma-related respiratory outcomes following vitamin D administration at a dose equal or greater than 500 IU per day were included and reviewed independently by two authors for full systematic review eligibility.

DATA EXTRACTION:

Two reviewers independently extracted and verified pre-defined data fields.

RESULTS:

We identified five studies that met study eligibility and assessed final data synthesis. The median trial size was 48 participants (range 17-430) and the average daily dose of cholecalciferol ranged from 500 to 2000‚ÄČIU/day. Overall study methodological quality was high, but some heterogeneity in population and vitamin D dosing regimen was evident. Meta-analysis suggested a statistically significant reduction (RR 0.41, CI 0.27-0.63) in asthma exacerbation with vitamin D therapy.

LIMITATIONS:

Due to variability in outcome selection and missing data, it was not possible to perform meta-analysis for pulmonary function testing and asthma symptom scores. Vitamin D-related adverse events were not considered in four of five papers.

CONCLUSIONS:

Available evidence from this systematic review suggests that high dose vitamin D may prevent asthma exacerbation. This should be confirmed through larger well-designed randomised controlled trials.

KEYWORDS:

Asthma; Vitamin D; asthma-related respiratory outcomes; children; systematic review

PMID:
25365192
DOI:
10.3109/02770903.2014.980509
[Indexed for MEDLINE]

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