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J Res Med Sci. 2014 Jul;19(7):658-64.

Metformin: Current knowledge.

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Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.


Diabetes mellitus is a group of metabolic disorders in which the blood glucose is higher than normal levels, due to insufficiency of insulin release or improper response of cells to insulin, resulting in high blood pressure. The resultant hyperglycemia produces sever complications. Metformin drug has been shown to prevent diabetes in people who are at high risk and decrease most of the diabetic complications. Recent reports on metformin, not only indicate some implications such as renoprotective properties have been suggested for metformin, but some reports indicate its adverse effects as well that are negligible when its benefits are brought into account. We aimed here to review the new implications of metformin and discuss about the concerns in the use of metformin, referring to the recently published papers.


Diabetes; diabetes mellitus; diabetic nephropathy; glucose; metformin; new applications; polycystic ovary syndrome; renoprotection


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