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Nat Rev Microbiol. 2015 Jan;13(1):7-12. doi: 10.1038/nrmicro3369. Epub 2014 Nov 3.

Novel functions of viral anti-apoptotic factors.

Author information

1
Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA.
2
Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.

Abstract

Cellular apoptosis is of major importance in the struggle between virus and host. Although many viruses use various strategies to control the cell death machinery by encoding anti-apoptotic virulence factors, it is now becoming clear that, in addition to their role in inhibiting apoptosis, these factors function in multiple immune and metabolic pathways to promote fitness and pathogenesis. In this Progress article, we discuss novel functions of viral anti-apoptotic factors in the regulation of autophagy, in the nuclear factor-κB (NF-κB) pathway and in interferon signalling, with a focus on persistent and oncogenic gammaherpesviruses. If viral anti-apoptotic proteins are to be properly exploited as targets for antiviral drugs, their diverse and complex roles should be considered.

PMID:
25363821
PMCID:
PMC4420620
DOI:
10.1038/nrmicro3369
[Indexed for MEDLINE]
Free PMC Article

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