Format

Send to

Choose Destination
Clin Oral Implants Res. 2016 Mar;27(3):354-60. doi: 10.1111/clr.12520. Epub 2014 Nov 3.

Bioresorbable zinc hydroxyapatite guided bone regeneration membrane for bone regeneration.

Author information

1
Advanced Tissue Regeneration and Drug Delivery Group, Faculty of Science, P.O.Box 123, Broadway, Sydney, NSW, 2007, Australia.
2
Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Tokyo, Japan.
3
Oral Implantology and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
4
Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.

Abstract

OBJECTIVES:

The aim of this study was to investigate the bone regenerative properties of a heat treated cross-linked GBR membrane with zinc hydroxyapatite powders in the rat calvarial defect model over a 6-week period.

MATERIAL AND METHODS:

In vitro physio-chemical characterization involved X-ray diffraction analysis, surface topology by scanning electron microscopy, and zinc release studies in physiological buffers. Bilateral rat calvarial defects were used to compare the Zn-HAp membranes against the commercially available collagen membranes and the unfilled defect group through radiological and histological evaluation.

RESULTS:

The synthesized Zn-MEM (100 μm thick) showed no zinc ions released in the phosphate buffer solution (PBS) buffer, but zinc was observed under acidic conditions. At 6 weeks, both the micro-CT and histological analyses revealed that the Zn-MEM group yielded significantly greater bone formation with 80 ± 2% of bone filled, as compared with 60 ± 5% in the collagen membrane and 40 ± 2% in the unfilled control group.

CONCLUSION:

This study demonstrated the use of heat treatment as an alternative method to cross-linking the Zn-MEM to be applied as a GBR membrane. Its synthesis and production are relatively simple to fabricate, and the membrane had rough surface features on one side, which might be beneficial for cellular activities. In a rat calvarial defect model, it was shown that new bone formation was accelerated in comparison with the collagen membrane and the unfilled defect groups. These results would suggest that Zn-MEM has the potential for further development in dental applications.

KEYWORDS:

GBR membrane; bone augmentation; bone regeneration; hydroxyapatite; implant therapy

PMID:
25363210
DOI:
10.1111/clr.12520
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center