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Influenza Other Respir Viruses. 2014 Nov;8(6):646-53. doi: 10.1111/irv.12289. Epub 2014 Nov 1.

A novel highly pathogenic H5N8 avian influenza virus isolated from a wild duck in China.

Author information

1
Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China; Research Center of Wildlife Disease, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun, China.

Abstract

Migrating wild birds are considered natural reservoirs of influenza viruses and serve as a potential source of novel influenza strains in humans and livestock. During routine avian influenza surveillance conducted in eastern China, a novel H5N8 (SH-9) reassortant influenza virus was isolated from a mallard duck in China. blast analysis revealed that the HA, NA, PB1, PA, NP, and M segments of SH-9 were most closely related to the corresponding segments of A/duck/Jiangsu/k1203/2010 (H5N8). The SH-9 virus preferentially recognized avian-like influenza virus receptors and was highly pathogenic in mice. Our results suggest that wild birds could acquire the H5N8 virus from breeding ducks and spread the virus via migratory bird flyways.

KEYWORDS:

H5N8; highly pathogenic avian influenza virus; wild duck

PMID:
25363159
PMCID:
PMC4262280
DOI:
10.1111/irv.12289
[Indexed for MEDLINE]
Free PMC Article

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