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Indian Pediatr. 2014 Oct;51(10):780-4.

Zinc supplementation for prevention of acute respiratory infections in infants: a randomized controlled trial.

Author information

1
Departments of Community Medicine and *Pediatrics, Maulana Azad Medical College, New Delhi, India; and #Indian Institute of Public Health, Gurgaon, Haryana, India. Correspondence to: Dr Akash Malik, National RMNCH+A Unit, Room No. 107 D, Ministry of Health and Family Welfare, Government of India, Nirman Bhawan, New Delhi 110 001, India. drakashmalik28@gmail.com.

Abstract

OBJECTIVE:

To study the effect of 2 weeks of prophylactic zinc supplementation on incidence and duration of acute respiratory infections.

DESIGN:

Randomized double blind controlled trial.

SETTING:

Community based; urban resettlement area in North-East Delhi, India.

PARTICIPANTS:

272 children aged 6-11 months with acute respiratory infections. Children receiving zinc supplement within the past 3 months, severely malnourished, immuno-deficient, on steroid therapy, with severe illness requiring hospitalization, or children of families likely to migrate from the study area were excluded.

INTERVENTION:

Placebo (syrup base) or zinc (20 mg/5 mL elemental zinc as zinc sulfate) orally given for a period of 2 weeks.

MAIN OUTCOME MEASURE(S):

Incidence, type and duration of acute respiratory infections, and adverse effects.

RESULTS:

No effect on incidence of acute respiratory infections was noted. A decrease of 15% (0.78-0.94) in days and 12% (0.78-0.94) in duration of episode in acute respiratory infections was observed. Incidence of acute lower respiratory infections decreased by 62% (0.26-0.36) and the effect remained for full five months of follow up. There were no drop outs due to side effects.

CONCLUSIONS:

Prophylactic zinc supplementation for two weeks may reduce the morbidity due to acute lower respiratory infections but not overall rate of acute respiratory infections in infants aged 6-11 months in similar populations.

PMID:
25362008
[Indexed for MEDLINE]
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