Expression of five proteins from the Sendai virus P/C mRNA in infected cells

J Virol. 1989 Feb;63(2):974-7. doi: 10.1128/JVI.63.2.974-977.1989.

Abstract

The polycistronic P/C mRNA of Sendai virus is translated under cell-free conditions into five proteins (P, C', C, Y1, and Y2) from overlapping reading frames. In this study, we showed that in addition to the P, C', and C proteins, Y1 and Y2 were expressed by six different Sendai virus strains in infected cells. The Y proteins exhibited strain-specific variation in their gel mobility which corresponds to the variation seen in the cognate C proteins. While the relative levels of the P, C', and C proteins were consistent among various cell lines, the levels of Y1 and Y2 proteins varied among the cell lines used for viral infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Line
  • Gene Expression Regulation
  • Genes
  • Genes, Viral*
  • Parainfluenza Virus 1, Human / genetics
  • Parainfluenza Virus 1, Human / metabolism*
  • RNA, Messenger / genetics*
  • RNA, Viral / genetics*
  • Viral Proteins / biosynthesis*
  • Viral Proteins / genetics

Substances

  • RNA, Messenger
  • RNA, Viral
  • Viral Proteins