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Nutrients. 2014 Oct 30;6(11):4805-21. doi: 10.3390/nu6114805.

Anti-stress effects of lemon balm-containing foods.

Author information

1
Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia. andrew@scholeylab.com.
2
Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia. amygibbs57@gmail.com.
3
Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia. chrisneale02@gmail.com.
4
Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia. naomiperry21@gmail.com.
5
Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia. apresgrave@gmail.com.
6
Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia. vanessa.bilog@gmail.com.
7
Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia. marni.kras@monash.edu.
8
Merck Selbstmedikation GmbH, Roesslerstrasse 96, 64293 Darmstadt, Germany. Claudia.Scholz@merck.de.
9
Rudolf Wild GmbH & Co. KG, Rudolf-Wild-Str. 107-115, D-69214 Eppelheim, Heidelberg, Germany. Matthias.Sass@wild.de.
10
Vital Solutions GmbH, Hausinger Strasse 6, D-40764 Langenfeld, Germany. Sybille.buchwald-werner@vitalsolutions.biz.

Abstract

Lemon balm (Melissa officinalis) has been used historically and contemporarily as a modulator of mood and cognitive function, with anxiolytic effects following administration of capsules, coated tablets and topical application. Following a pilot study with lemon balm extract administered as a water based drink, which confirmed absorption of rosmarinic acid effects on mood and cognitive function, we conducted two similar double-blind, placebo-controlled, crossover studies. These evaluated the mood and cognitive effects of a standardised M. officinalis preparation administered in palatable forms in a beverage and in yoghurt. In each study a cohort of healthy young adults' self-rated aspects of mood were measured before and after a multi-tasking framework (MTF) administered one hour and three hours following one of four treatments. Both active lemon balm treatments were generally associated with improvements in mood and/or cognitive performance, though there were some behavioral "costs" at other doses and these effects depended to some degree on the delivery matrix.

PMID:
25360512
PMCID:
PMC4245564
DOI:
10.3390/nu6114805
[Indexed for MEDLINE]
Free PMC Article

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