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Andrologia. 2015 Nov;47(9):974-9. doi: 10.1111/and.12366. Epub 2014 Oct 30.

Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males.

Author information

1
Medfem Clinic, Bryanston, South Africa.
2
Biostatistics Unit, Medical Research Council and Division of Clinical Epidemiology, University of Pretoria, Pretoria, South Africa.
3
Department of Biomedical Sciences, Tshwane University of Technology, Pretoria, South Africa.

Abstract

Previous reports indicated that hyperinsulinaemic men may exhibit a higher percentage of poorly compacted DNA in their spermatozoa and less success in an IVF programme (Andrologia, 45, 2003, 18; Andrologia, 2014, doi: 10.1111/and.12227). The aim of this study was to investigate the effect of metformin (Glucophage®) and antioxidant treatment (StaminoGro®) on the semen parameters of hyperinsulinaemic men. Nineteen hyperinsulinaemic male patients were treated for 3 months with metformin alone (Group A), and fifteen patients used metformin in combination with the nutritional supplement (Group B). Combined data of the two groups (pre- and post-treatment) differ significantly regarding sperm morphology (P = 0.0003) and CMA3 (P < 0.0001) values. The improvement in sperm morphology after treatment was similar for the two respective groups (P < 0.05). The morphological normal sperm forms increased from the mean percentage of 3.9 to 5.5% and from 4.2 to 5.5% for Group A and B respectively. Where a combination of metformin and the supplement were used (Group B), the combination treatment proved to be superior in obtaining enhanced chromatin packaging quality although not statistically significant (P = 0.5929) when compared with the metformin (Group A) group. The chromatin packaging quality in Group B improved with 10% while the improvement in Group A was approximately 8.3%. Therefore, infertile hyperinsulinaemic men can benefit from metformin treatment and should be advised on the use of nutritional supplements with antioxidant properties.

KEYWORDS:

CMA 3; male hyperinsulinaemia; metformin; morphology; nutritional supplement

PMID:
25359661
DOI:
10.1111/and.12366
[Indexed for MEDLINE]

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