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Stem Cell Reports. 2014 Oct 14;3(4):620-33. doi: 10.1016/j.stemcr.2014.08.007. Epub 2014 Sep 18.

BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions.

Author information

1
Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, 28(th) Floor Tower Wing, Great Maze Pond, London SE1 9RT, UK; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
2
Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Biochemistry and Molecular Biology, Monash University, Building 76, Wellington Road, Clayton, VIC 3800, Australia.
3
Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, 28(th) Floor Tower Wing, Great Maze Pond, London SE1 9RT, UK; Epithelial Cell Biology Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
4
Graduate Institute of Life Sciences, National Defense Medical Centre, Taipei 114, Taiwan, ROC; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan, ROC.
5
Epithelial Cell Biology Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK; Clinic of Dermatology and Venereology, Otto-von-Guericke University, Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.
6
Clinic of Dermatology and Venereology, Otto-von-Guericke University, Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.
7
Epithelial Cell Biology Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK; Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Sapporo 060-8638, Japan.
8
Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, 28(th) Floor Tower Wing, Great Maze Pond, London SE1 9RT, UK. Electronic address: fiona.watt@kcl.ac.uk.

Abstract

B-lymphocyte-induced nuclear maturation protein 1 (BLIMP1) was previously reported to define a sebaceous gland (SG) progenitor population in the epidermis. However, the recent identification of multiple stem cell populations in the hair follicle junctional zone has led us to re-evaluate its function. We show, in agreement with previous studies, that BLIMP1 is expressed by postmitotic, terminally differentiated epidermal cells within the SG, interfollicular epidermis, and hair follicle. Epidermal overexpression of c-Myc results in loss of BLIMP1(+) cells, an effect modulated by androgen signaling. Epidermal-specific deletion of Blimp1 causes multiple differentiation defects in the epidermis in addition to SG enlargement. In culture, BLIMP1(+) sebocytes have no greater clonogenic potential than BLIMP1(-) sebocytes. Finally, lineage-tracing experiments reveal that, under steady-state conditions, BLIMP1-expressing cells do not divide. Thus, rather than defining a sebocyte progenitor population, BLIMP1 functions in terminally differentiated cells to maintain homeostasis in multiple epidermal compartments.

PMID:
25358790
PMCID:
PMC4223714
DOI:
10.1016/j.stemcr.2014.08.007
[Indexed for MEDLINE]
Free PMC Article

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