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Eur Heart J. 2015 Jan 14;36(3):170-8. doi: 10.1093/eurheartj/ehu407. Epub 2014 Oct 29.

Prognostic impact of supraventricular premature complexes in community-based health checkups: the Ibaraki Prefectural Health Study.

Author information

1
Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan n.murakoshi@md.tsukuba.ac.jp.
2
Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan.
3
Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan Department of Public Health, Dokkyo Medical University, Mibu, Japan.
4
Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan Department of Health and Welfare, Ibaraki Prefectural Office, Mito, Japan.
5
Ibaraki Health Service Association, Mito, Japan.
6
Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan.
7
Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan Department of Public Health Medicine, University of Tsukuba, Tsukuba, Japan.
8
Department of Social and Environmental Medicine, Osaka University, Osaka, Japan.
9
Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan.

Abstract

AIMS:

The long-term prognosis of subjects with supraventricular premature complexes (SVPCs) remains unclear in the general population. The aim of this study was to examine the prognostic significance of SVPCs in community-based health checkups.

METHODS AND RESULTS:

We assessed 63 197 individuals (mean age, 58.8 ± 9.9 years; 67.6% women) who participated in annual community-based health checkups in 1993 and were followed until 2008. The primary endpoint was stroke death, cardiovascular death (CVD), or all-cause death during a 14-year mean follow-up, and the secondary endpoint was first atrial fibrillation (AF) event in subjects without self-reported heart diseases or AF at baseline. Compared with subjects without SVPCs, the multivariate-adjusted hazard ratios (HRs) [95% confidence interval (CI)] of stroke death, CVD, and all-cause death in subjects with SVPCs were 1.24 (0.98-1.56) for men and 1.63 (1.30-2.05) for women, 1.22 (1.04-1.44) for men and 1.48 (1.25-1.74) for women, and 1.08 (0.99-1.18) for men and 1.21 (1.09-1.34) for women, respectively. Atrial fibrillation occurred in 386 subjects during the follow-up (1.05/1000 person-years). The presence of SVPCs at baseline was the significant predictor of AF onset [HRs (95% CI): 4.87 (3.61-6.57) for men and 3.87 (2.69-5.57) for women]. Propensity score matched analyses also revealed the presence of SVPCs was significantly associated with increased risks of AF incidence and CVD even after adjusting the potential confounders.

CONCLUSION:

The presence of SVPCs in 12-lead electrocardiograms was a strong predictor of AF development, and associated with increased risk of CVD in general population.

KEYWORDS:

Atrial fibrillation; Electrocardiogram; Mortality; Supraventricular premature complex

PMID:
25358506
DOI:
10.1093/eurheartj/ehu407
[Indexed for MEDLINE]

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