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Nat Cell Biol. 2014 Nov;16(11):1031-3. doi: 10.1038/ncb3055.

Cyclin C surprises in tumour suppression.

Author information

1
Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain.

Abstract

Despite the importance of cyclins and cyclin-dependent kinases (Cdks) in the control of cell division, the physiological role of many of these regulators remains unknown. Cyclin C and its associated kinases Cdk3, Cdk8 and Cdk19 are now shown to function as tumour suppressors in haematopoietic malignancies by inhibiting the Notch1 pathway.

PMID:
25358351
DOI:
10.1038/ncb3055
[Indexed for MEDLINE]

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