Format

Send to

Choose Destination
PLoS One. 2014 Oct 30;9(10):e111383. doi: 10.1371/journal.pone.0111383. eCollection 2014.

Bisphenol A exposure and asthma development in school-age children: a longitudinal study.

Author information

1
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
2
Institute of Environmental Medicine, Medical Research Center, Seoul, Korea.
3
Department of Preventive Medicine and Public Health, Dankook University College of Medicine, Cheonan, Korea.
4
Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standardization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
5
Department of Pediatrics, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
6
Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
7
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; Institute of Environmental Medicine, Medical Research Center, Seoul, Korea.

Abstract

BACKGROUND:

Although the effect of bisphenol A on various health outcomes has been extensively examined, few studies have investigated its effect on asthma.

OBJECTIVE:

We hypothesized that exposure to bisphenol A in school-age children was associated with wheezing and asthma.

METHODS:

Participants included 127 children aged 7-8 years without a previous asthma diagnosis in an elementary school in Seoul, Korea. Three surveys were conducted, each 2 years apart. Bisphenol A concentration was measured at the baseline survey, and PC20, which is defined as the methacholine concentration that induces a decrease in FEV1 of 20% from baseline, was measured at every survey. Associations between bisphenol A concentration at 7-8 years of age and wheezing, asthma, and PC20 at ages up to 11-12 years were examined using generalized estimating equations, a marginal Cox regression model, and a linear mixed model.

RESULTS:

The log-transformed creatinine-adjusted urinary bisphenol A concentration at 7-8 years was positively associated with wheezing (odds ratio, 2.48; 95% confidence interval, 1.15-5.31; P = .02) and asthma (hazard ratio, 2.13; 95% confidence interval, 1.51-3.00; P<.001) at ages up to 11-12 years. Bisphenol A was also negatively associated with PC20 (ß = -2.33; P = .02). When stratified by sex, the association between bisphenol A and asthma remained significant only in girls (hazard ratio, 2.45; 95% confidence interval, 2.18-2.76; P<.001).

CONCLUSION:

Increased urinary bisphenol A concentrations at 7-8 years old were positively associated with wheezing and asthma and negatively associated with PC20 at ages up to 11-12 years.

PMID:
25356742
PMCID:
PMC4214730
DOI:
10.1371/journal.pone.0111383
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center