Format

Send to

Choose Destination
Genome Biol Evol. 2014 Oct 28;6(11):2998-3014. doi: 10.1093/gbe/evu238.

Conserved and divergent patterns of DNA methylation in higher vertebrates.

Author information

1
Department of Biostatistics & Computational Biology, SKLG, School of Life Sciences, Fudan University, Shanghai, China School of Biosciences, The University of Birmingham, Birmingham B15 2TT United Kingdom.
2
Department of Biostatistics & Computational Biology, SKLG, School of Life Sciences, Fudan University, Shanghai, China.
3
School of Biosciences, The University of Birmingham, Birmingham B15 2TT United Kingdom.
4
School of Biosciences, The University of Birmingham, Birmingham B15 2TT United Kingdom zwluo@fudan.edu.cn l.j.leach@bham.ac.uk.
5
Department of Biostatistics & Computational Biology, SKLG, School of Life Sciences, Fudan University, Shanghai, China School of Biosciences, The University of Birmingham, Birmingham B15 2TT United Kingdom zwluo@fudan.edu.cn l.j.leach@bham.ac.uk.

Abstract

DNA methylation in the genome plays a fundamental role in the regulation of gene expression and is widespread in the genome of eukaryotic species. For example, in higher vertebrates, there is a "global" methylation pattern involving complete methylation of CpG sites genome-wide, except in promoter regions that are typically enriched for CpG dinucleotides, or so called "CpG islands." Here, we comprehensively examined and compared the distribution of CpG sites within ten model eukaryotic species and linked the observed patterns to the role of DNA methylation in controlling gene transcription. The analysis revealed two distinct but conserved methylation patterns for gene promoters in human and mouse genomes, involving genes with distinct distributions of promoter CpGs and gene expression patterns. Comparative analysis with four other higher vertebrates revealed that the primary regulatory role of the DNA methylation system is highly conserved in higher vertebrates.

KEYWORDS:

CpG sites within promoters; comparative phylogenetic analysis; conservation and divergence in DNA methylation; eukaryotes; genome-wide CpG site distribution

PMID:
25355807
PMCID:
PMC4255770
DOI:
10.1093/gbe/evu238
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center