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Cell Mol Life Sci. 2015 Feb;72(3):537-556. doi: 10.1007/s00018-014-1760-7. Epub 2014 Oct 30.

Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse.

Author information

1
Immunology Program, Memorial Sloan-Kettering Cancer Center, Box 514, 1275 York Ave, New York, NY, 10065, USA.
2
Immunology Program, Memorial Sloan-Kettering Cancer Center, Box 514, 1275 York Ave, New York, NY, 10065, USA. husem@mskcc.org.

Abstract

Transient,specialized cell-cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function.

PMID:
25355055
PMCID:
PMC4294954
DOI:
10.1007/s00018-014-1760-7
[Indexed for MEDLINE]
Free PMC Article

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