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Eur Arch Otorhinolaryngol. 2016 Mar;273(3):537-45. doi: 10.1007/s00405-014-3339-1. Epub 2014 Oct 30.

Frequent chromosomal aberrations and candidate genes in head and neck squamous cell carcinoma.

Author information

1
Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
2
Department of Otolaryngology and Laryngeal Oncology, K. Marcinkowski University of Medical Sciences, Poznan, Poland.
3
Department of Pathology and Laboratory Services, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
4
University of Udine School of Medicine, Udine, Italy.
5
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
6
Instituto Universitario de OncologĂ­a del Principado de Asturias, Oviedo, Spain.
7
Department of Otolaryngology Head and Neck Surgery, Radboud University Medicine Center, Nijmegen, The Netherlands.
8
University of Udine School of Medicine, Udine, Italy. a.ferlito@uniud.it.

Abstract

The knowledge of the biology of head and neck squamous cell carcinoma (HNSCC) has had relatively little impact on the improvement in oncologic outcome up to date. However, the identification of oncogenes and tumor suppressor genes (TSGs) involved in cancer progression contributes to the understanding of the molecular pathways involved in oncogenesis and could contribute to individual risk assessment and provide tools for improvement of treatment and targets for therapy based on the alterations in these pathways. The aim of this article is to review the chromosomal aberrations commonly found in HNSCC, to identify the genes in these chromosomal regions suggested to act as (candidate) oncogenes or TSGs, and to discuss the molecular mechanisms modulating their expression.

KEYWORDS:

Chromosome alterations; Head and neck carcinoma; Markers of progression; Oncogenes; Tumor suppressor genes

PMID:
25355032
DOI:
10.1007/s00405-014-3339-1
[Indexed for MEDLINE]

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