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J Med Food. 2015 Jan;18(1):102-8. doi: 10.1089/jmf.2013.3138.

Lipid-soluble ginseng extract inhibits invasion and metastasis of B16F10 melanoma cells.

Author information

1
1 Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology , Ochang, Republic of Korea.

Abstract

This study was performed to elucidate the effect of a lipid-soluble ginseng extract (LSGE) on cancer invasion and metastasis. The LSGE, even at noncytotoxic concentrations, potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner. In the presence of 3 μg/mL of LSGE, the invasion and migration of B16F10 cells were significantly inhibited by 98.1% and 71.4%, respectively. Furthermore, the LSGE decreased mRNA and protein levels of matrix metalloproteinase (MMP)-2 in B16F10 cells, leading to a decrease in MMP-2 activity. After B16F10 cells were intravenously injected in the tail vein of C57BL/6 mice, 1000 mg/kg/day of LSGE was orally administered for 13 days, after which lung metastasis of cancer cells was inhibited by 59.3%. These findings indicate that LSGE inhibits cancer cell invasion and migration in vitro and lung metastasis of melanoma cells in vivo by inhibiting MMP-2 expression.

KEYWORDS:

cancer invasion; lipid-soluble ginseng extract; lung metastasis; matrix metalloprotease-2

PMID:
25354136
PMCID:
PMC4281846
DOI:
10.1089/jmf.2013.3138
[Indexed for MEDLINE]
Free PMC Article

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