Format

Send to

Choose Destination
Curr Opin Endocrinol Diabetes Obes. 2014 Dec;21(6):431-6. doi: 10.1097/MED.0000000000000108.

Vitamin D for infections.

Author information

1
Clinical and Experimental Endocrinology, Department of Experimental and Clinical Medicine, KU Leuven, Leuven, Belgium.

Abstract

PURPOSE OF REVIEW:

Current data clearly support an interaction of vitamin D with cells of the immune system apart from its regulatory role in calcium homeostasis. The discovery that immune cells express the vitamin D receptor and are capable of metabolizing circulating 25-hydroxyvitamin D into its active form, 1,25-dihydroxyvitamin D, has revolutionized the field and suggested a regulatory role on both the innate and adaptive immune systems.

RECENT FINDINGS:

Of particular interest with respect to infectious diseases, 1,25-dihydroxyvitamin D has been shown to trigger the production of antimicrobial peptides with a direct pathogen-killing capacity. Interestingly, pathogen-derived components influence the key players in the vitamin D metabolizing pathway, further supporting such an interaction.

SUMMARY:

Here, we review the potential mechanisms of vitamin D in promoting the innate immune response against infectious agents and discuss the possible implications for such a response in the prevention of or the intervention in various infectious diseases.

PMID:
25354043
DOI:
10.1097/MED.0000000000000108
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center