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Front Cell Infect Microbiol. 2014 Oct 14;4:145. doi: 10.3389/fcimb.2014.00145. eCollection 2014.

Fungal glycans and the innate immune recognition.

Author information

1
Departamento de Microbiologia Geral, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil.
2
Instituto de Ciências Biomédicas/Unidade de Xerém, Universidade Federal do Rio de Janeiro Rio de Janeiro, Brazil.

Abstract

Polysaccharides such as α- and β-glucans, chitin, and glycoproteins extensively modified with both N- and O-linked carbohydrates are the major components of fungal surfaces. The fungal cell wall is an excellent target for the action of antifungal agents, since most of its components are absent from mammalian cells. Recognition of these carbohydrate-containing molecules by the innate immune system triggers inflammatory responses and activation of microbicidal mechanisms by leukocytes. This review will discuss the structure of surface fungal glycoconjugates and polysaccharides and their recognition by innate immune receptors.

KEYWORDS:

fungal pathogens; glycoconjugates; innate immunity; pattern recognition receptors; polysaccharides

PMID:
25353009
PMCID:
PMC4196476
DOI:
10.3389/fcimb.2014.00145
[Indexed for MEDLINE]
Free PMC Article

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